Opening book details…
Can I read Downregulation of microRNA‐183‐5p inhibits the proliferation and invasion of colorectal cancer cells by inactivating the reticulocalbin‐2/Wnt/β‐catenin signaling pathway on EtoBox?
Downregulation of microRNA‐183‐5p inhibits the proliferation and invasion of colorectal cancer cells by inactivating the reticulocalbin‐2/Wnt/β‐catenin signaling pathway by Gang Wang; Jingrong Zhou; Feng Lu; Lei Qiu; Liang Xu; Xiuwei Yang; Yongchang Miao is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Downregulation of microRNA‐183‐5p inhibits the proliferation and invasion of colorectal cancer cells by inactivating the reticulocalbin‐2/Wnt/β‐catenin signaling pathway about?
microRNAs (miRNAs) are frequently aberrantly expressed in colorectal cancer (CRC) and are considered to serve a critical role in the onset and development of CRC by binding to its target transcription factor. The aim of the present study was to examine the role of miRNA (miR)‐183‐5p in the proliferation, invasion and migration of CRC cells, in addition to its underlying mechanism. Reverse transcription‐quantitative polymerase chain reaction analysis was used to detect the expression level of miR‐183‐5p. MTT and Transwell assays were performed to examine proliferation and invasion in SW620 cells. Western blot analysis was performed to determine the protein expression of reticulocalbin‐2 (RCN2), matrix metalloproteinase‐2, β‐catenin, cyclin D1 and c‐Myc. miR‐183‐5p expression was significantly upregulated in the CRC tissues compared with adjacent normal tissues. In addition, the inhibition of miR‐183‐5p suppressed proliferation, invasion and migration in SW620 cells. miR‐183‐5p downregulation or overexpression regulated the CRC cell cycle, invasion and migration by modulating RCN2 expression. Furthermore, the Wnt/β‐catenin pathway was observed to be involved in the inhibitory effect
Who reads Downregulation of microRNA‐183‐5p inhibits the proliferation and invasion of colorectal cancer cells by inactivating the reticulocalbin‐2/Wnt/β‐catenin signaling pathway?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Gang Wang; Jingrong Zhou; Feng Lu; Lei Qiu; Liang Xu; Xiuwei Yang; Yongchang Miao
- Publisher
- Spandidos Publications Ltd; Spandidos Publications (ISSN 1791-2997)
- Published
- 2019
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)