Opening book details…
Can I read Polydopamine-doped Supramolecular Chiral Hydrogels for Postoperative Tumor Recurrence Inhibition and Simultaneously Enhanced Wound Repair on EtoBox?
Polydopamine-doped Supramolecular Chiral Hydrogels for Postoperative Tumor Recurrence Inhibition and Simultaneously Enhanced Wound Repair by Xueqian Wang; Beibei Wu; Yaqian Zhang; Xiaoqiu Dou; Changli Zhao; Chuanliang Feng is a Engineering article available to read on EtoBox.
What is Polydopamine-doped Supramolecular Chiral Hydrogels for Postoperative Tumor Recurrence Inhibition and Simultaneously Enhanced Wound Repair about?
Cancer recurrence remains a major challenge after primary tumor excision, and the inflammation of tumor-caused wounds can hinder wound healing and potentially promote tumor growth. Herein, a chiral L-phenylalanine-based (LPFEG) supramolecular hydrogel system encapsulated with polydopamine nanoparticles (PDA-NPs) has been developed in order to prevent tumor relapse after surgery and promote wound repair. PDA-NPs allow for near-infrared (NIR) light-triggered photothermal therapy, especially, it can scavenge free radicals in the surgical wound. LPFEG can mimic native extracellular matrix (ECM) structure to create a chiral microenvironment that enhances fibroblast adhesion, proliferation, and new tissue regeneration. With anticancer drug doxorubicin (DOX) loaded into the composite hydrogel, the antitumor effect is significantly enhanced by the integration of chemo-photothermal therapy both in vitro and in vivo. The PDA-based chiral supramolecular composite hydrogel as an effective postoperative adjuvant possesses promising applicable prospects in inhibiting tumor recurrence and accelerating wound healing after operation. STATEMENT OF SIGNIFICANCE: After primary tumor excision, cancer r
Who reads Polydopamine-doped Supramolecular Chiral Hydrogels for Postoperative Tumor Recurrence Inhibition and Simultaneously Enhanced Wound Repair?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Xueqian Wang; Beibei Wu; Yaqian Zhang; Xiaoqiu Dou; Changli Zhao; Chuanliang Feng
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Engineering (Physical Sciences)