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Can I read Redox-Responsive Core-Cross-Linked Micelles of Miktoarm Poly(ethylene oxide)- b -poly(furfuryl methacrylate) for Anticancer Drug Delivery on EtoBox?
Redox-Responsive Core-Cross-Linked Micelles of Miktoarm Poly(ethylene oxide)- b -poly(furfuryl methacrylate) for Anticancer Drug Delivery by Parveen Kumar; Seon-Hwa Kim; Sonyabapu Yadav; Sung-Han Jo; Seong Yoo; Sang-Hyug Park; Kwon Taek Lim is a Engineering article available to read on EtoBox.
What is Redox-Responsive Core-Cross-Linked Micelles of Miktoarm Poly(ethylene oxide)- b -poly(furfuryl methacrylate) for Anticancer Drug Delivery about?
The physiological instability of nanocarriers, premature drug leakage during blood circulation, and associated severe side effects cause compromised therapeutic efficacy, which have significantly hampered the progress of nanomedicines. The cross-linking of nanocarriers while keeping the effectiveness of their degradation at the targeted site to release the drug has emerged as a potent strategy to overcome these flaws. Herein, we have designed novel (poly(ethylene oxide)) 2 -b-poly(furfuryl methacrylate) ((PEO 2K ) 2 -b-PFMA nk ) miktoarm amphiphilic block copolymers by coupling alkynefunctionalized PEO (PEO 2K -CH) and diazide-functionalized poly(furfuryl methacrylate) ((N 3 ) 2 -PFMA nk ) via click chemistry. (PEO 2K ) 2 -b-PFMA nk selfassembled to form nanosized micelles (mikUCL) with hydrodynamic radii in the range of 25∼33 nm. The hydrophobic core of mikUCL was cross-linked by a disulfide-containing cross-linker using the Diels−Alder reaction to avoid unwanted leakage and burst release of a payload. As expected, the resulting core-cross-linked (PEO 2K ) 2 -b-PFMA nk micelles (mikCCL) exhibited superior stability under a normal physiological environment and were de-cross-linked
Who reads Redox-Responsive Core-Cross-Linked Micelles of Miktoarm Poly(ethylene oxide)- b -poly(furfuryl methacrylate) for Anticancer Drug Delivery?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Parveen Kumar; Seon-Hwa Kim; Sonyabapu Yadav; Sung-Han Jo; Seong Yoo; Sang-Hyug Park; Kwon Taek Lim
- Publisher
- American Chemical Society (ACS)
- Published
- 2023
- Language
- EN
- Field
- Engineering (Physical Sciences)