Skip to content

Opening book details…

Can I read Protective Role of Endothelial Fibulin‐4 in Valvulo‐Arterial Integrity on EtoBox?

Protective Role of Endothelial Fibulin‐4 in Valvulo‐Arterial Integrity by Nguyen, Tram Anh Vu (author);Lino, Caroline Antunes (author);Hang, Huynh Thuy (author);Alves, Juliano Vilela (author);Thang, Bui Quoc (author);Shin, Seung Jae (author);Sugiyama, Kaori (author);Matsunaga, Hiroko (author);Takeyama, Haruko (author);Yamashiro, Yoshito (author);Yanagisawa, Hiromi (author) is a Medicine article available to read on EtoBox.

What is Protective Role of Endothelial Fibulin‐4 in Valvulo‐Arterial Integrity about?

## Background Homeostasis of the vessel wall is cooperatively maintained by endothelial cells (ECs), smooth muscle cells, and adventitial fibroblasts. The genetic deletion of fibulin‐4 ( __Fbln4__ ) in smooth muscle cells ( __SMKO__ ) leads to the formation of thoracic aortic aneurysms with the disruption of elastic fibers. Although __Fbln4__ is expressed in the entire vessel wall, its function in ECs and relevance to the maintenance of valvulo‐arterial integrity are not fully understood. ## Methods and Results Gene silencing of __FBLN4__ was conducted on human aortic ECs to evaluate morphological changes and gene expression profile. __Fbln4__ double knockout ( __DKO__ ) mice in ECs and smooth muscle cells were generated and subjected to histological analysis, echocardiography, Western blotting, RNA sequencing, and immunostaining. An evaluation of the thoracic aortic aneurysm phenotype and screening of altered signaling pathways were performed. Knockdown of __FBLN4__ in human aortic ECs induced mesenchymal cell–like changes with the upregulation of mesenchymal genes, including __TAGLN__ and __MYL9__ . __DKO__ mice showed the exacerbation of thoracic aortic aneurysms when compared w

Who reads Protective Role of Endothelial Fibulin‐4 in Valvulo‐Arterial Integrity?

It is typically read by researchers, students, and practitioners in Medicine.

Author
Nguyen, Tram Anh Vu (author);Lino, Caroline Antunes (author);Hang, Huynh Thuy (author);Alves, Juliano Vilela (author);Thang, Bui Quoc (author);Shin, Seung Jae (author);Sugiyama, Kaori (author);Matsunaga, Hiroko (author);Takeyama, Haruko (author);Yamashiro, Yoshito (author);Yanagisawa, Hiromi (author)
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2023
Language
EN
Field
Medicine (Health Sciences)

More by Nguyen, Tram Anh Vu (author);Lino, Caroline Antunes (author);Hang, Huynh Thuy (author);Alves, Juliano Vilela (author);Thang, Bui Quoc (author);Shin, Seung Jae (author);Sugiyama, Kaori (author);Matsunaga, Hiroko (author);Takeyama, Haruko (author);Yamashiro, Yoshito (author);Yanagisawa, Hiromi (author)

Browse all works by Nguyen, Tram Anh Vu (author);Lino, Caroline Antunes (author);Hang, Huynh Thuy (author);Alves, Juliano Vilela (author);Thang, Bui Quoc (author);Shin, Seung Jae (author);Sugiyama, Kaori (author);Matsunaga, Hiroko (author);Takeyama, Haruko (author);Yamashiro, Yoshito (author);Yanagisawa, Hiromi (author)