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Can I read Metal-Catalyzed C–N Bond Forming Reaction Selection and Process Development for the Manufacture of AZD7594 on EtoBox?
Metal-Catalyzed C–N Bond Forming Reaction Selection and Process Development for the Manufacture of AZD7594 by Gulsevim Aydin; Matthew Ball; Thomas George Bishop; Matthew Burns; Andrew D. Campbell; Robert J. Cox; Kuangchu Dai; David Dave; Heidi Fisk; Laura Hamilton; Claire Heffernan; Jean-Marc Henry; Stephen W. Holman; Martin F. Jones; Gary Noonan; Bharti Patel; David Streather; Simone Tomasi is a Chemistry article available to read on EtoBox.
What is Metal-Catalyzed C–N Bond Forming Reaction Selection and Process Development for the Manufacture of AZD7594 about?
Process development activities required to develop a robust and scalable synthetic route to AZD7594 (1) are disclosed. Included in this paper is the rationale for the selection of a palladium-mediated Buchwald-Hartwig coupling to form a key C-N bond. Reaction optimization and understanding were performed to minimize impurity formation and to develop a robust control strategy. The optimized synthetic sequence was used to manufacture 220 kg of AZD7594 (1) for clinical trials.
Who reads Metal-Catalyzed C–N Bond Forming Reaction Selection and Process Development for the Manufacture of AZD7594?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Gulsevim Aydin; Matthew Ball; Thomas George Bishop; Matthew Burns; Andrew D. Campbell; Robert J. Cox; Kuangchu Dai; David Dave; Heidi Fisk; Laura Hamilton; Claire Heffernan; Jean-Marc Henry; Stephen W. Holman; Martin F. Jones; Gary Noonan; Bharti Patel; David Streather; Simone Tomasi
- Publisher
- American Chemical Society (ACS)
- Published
- 2024
- Language
- EN
- Field
- Chemistry (Physical Sciences)