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Knowing Which and Knowing What: a Potential Mouse Model for Age-related Human Declarative Memory Decline by Aline Marighetto; Nicole Etchamendy; Khalid Touzani; Cedric Cortes Torrea; Benjamin K. Yee; John Nicholas P. Rawlins; Robert Jaffard is a Neuroscience article available to read on EtoBox.
What is Knowing Which and Knowing What: a Potential Mouse Model for Age-related Human Declarative Memory Decline about?
## Abstract The present study was built on the original report of Eichenbaum __et al__. [Eichenbaum, H., Fagan, A., Mathews, P. & Cohen, N.J. (1988), Behav. Neurosci., 102, 3531–3542] on the contrasting effects of fornix lesion in different versions of an odour‐guided discrimination task in rats, and attempted to extend this into a mouse model for the preferential loss of declarative memory seen in human senescence. Each of the two experiments reported here consisted of a two‐stage paradigm, with an initial learning phase followed by a test phase. The information acquired in the first stage was identical in both experiments, i.e. the valence or reward contingency associated with six (three positive and three negative) arms of a radial maze. The only parameter which was varied between Experiment A and B, and also between the two successive stages within each experiment, was the way of presenting the arms to the mice, i.e. either in pairs (simultaneous discriminations) or one at a time (successive go : no‐go discrimination). Performance in the first stage demonstrated that our aged mice were impaired in learning concurrent simultaneous discriminations but not successive go/no‐go disc
Who reads Knowing Which and Knowing What: a Potential Mouse Model for Age-related Human Declarative Memory Decline?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Aline Marighetto; Nicole Etchamendy; Khalid Touzani; Cedric Cortes Torrea; Benjamin K. Yee; John Nicholas P. Rawlins; Robert Jaffard
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0953-816X)
- Published
- 1999
- Language
- EN
- Field
- Neuroscience (Life Sciences)