Opening book details…
Can I read Physiological implications of DLX homeoproteins in enamel formation on EtoBox?
Physiological implications of DLX homeoproteins in enamel formation by Frédéric Lézot; Bethan Thomas; Scott R. Greene; Dominique Hotton; Zhi‐An Yuan; Beatriz Castaneda; Alba Bolaños; Michael Depew; Paul Sharpe; Carolyn W. Gibson; Ariane Berdal is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Physiological implications of DLX homeoproteins in enamel formation about?
## Abstract Tooth development is a complex process including successive stages of initiation, morphogenesis, and histogenesis. The role of the __Dlx__ family of homeobox genes during the early stages of tooth development has been widely analyzed, while little data has been reported on their role in dental histogenesis. The expression pattern of __Dlx2__ has been described in the mouse incisor; an inverse linear relationship exists between the level of __Dlx2__ expression and enamel thickness, suggesting a role for __Dlx2__ in regulation of ameloblast differentiation and activity. In vitro data have revealed that DLX homeoproteins are able to regulate the expression of matrix proteins such as osteocalcin. The aim of the present study was to analyze the expression and function of __Dlx__ genes during amelogenesis. Analysis of __Dlx2__/__LacZ__ transgenic reporter mice, __Dlx2__ and __Dlx1__/__Dlx2__ null mutant mice, identified spatial variations in __Dlx2__ expression within molar tooth germs and suggests a role for __Dlx__2 in the organization of preameloblastic cells as a palisade in the labial region of molars. Later, during the secretory and maturation stages of amelogenesis, th
Who reads Physiological implications of DLX homeoproteins in enamel formation?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Frédéric Lézot; Bethan Thomas; Scott R. Greene; Dominique Hotton; Zhi‐An Yuan; Beatriz Castaneda; Alba Bolaños; Michael Depew; Paul Sharpe; Carolyn W. Gibson; Ariane Berdal
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0021-9541)
- Published
- 2008
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)