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Can I read Adaptive Changes in Micromechanical Environments of Cancellous and Cortical Bone in Response to In Vivo Loading and Disuse on EtoBox?
Adaptive Changes in Micromechanical Environments of Cancellous and Cortical Bone in Response to In Vivo Loading and Disuse by Yang, Haisheng; Xu, Xiaoyu; Bullock, Whitney; Main, Russell P. is a Medicine article available to read on EtoBox.
What is Adaptive Changes in Micromechanical Environments of Cancellous and Cortical Bone in Response to In Vivo Loading and Disuse about?
The skeleton accommodates changes in mechanical environments by increasing bone mass under increased loads and decreasing bone mass under disuse. However, little is known about the adaptive changes in micromechanical behavior of cancellous and cortical tissues resulting from loading or disuse. To address this issue, in vivo tibial loading and hindlimb unloading experiments were conducted on 16-week-old female C57BL/6J mice. Changes in bone mass and tissue-level strains in the metaphyseal cancellous and midshaft cortical bone of the tibiae, resulting from loading or unloading, were determined using microCT and finite element (FE) analysis, respectively. We found that loading- and unloading-induced changes in bone mass were more pronounced in the cancellous than cortical bone. Simulated FE-loading showed that a greater proportion of elements experienced relatively lower longitudinal strains following load-induced bone adaptation, while the opposite was true in the disuse model. While the magnitudes of maximum or minimum principal strains in the metaphyseal cancellous and midshaft cortical bone were not affected by loading, strains oriented with the long axis were reduced in the load-
Who reads Adaptive Changes in Micromechanical Environments of Cancellous and Cortical Bone in Response to In Vivo Loading and Disuse?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Yang, Haisheng; Xu, Xiaoyu; Bullock, Whitney; Main, Russell P.
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0021-9290)
- Published
- 2019
- Language
- EN
- Field
- Medicine (Health Sciences)
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