About this Medicine article
CAR T-cell therapy and critical care: A survival guide for medical emergency teams by Anna S. Messmer; Yok-Ai Que; Christoph Schankin; Yara Banz; Ulrike Bacher; Urban Novak; Thomas Pabst is a Medicine article available to read on EtoBox.
## Summary Chimeric antigen receptor (CAR) T‐cells are genetically engineered to give T‐cells the ability to attack specific cancer cells, and to improve outcome of patients with refractory/relapsed aggressive B‐cell malignancies. To date, several CAR T‐cell products are approved and additional products with similar indication or extended to other malignancies are currently being evaluated. Side effects of CAR T‐cell treatment are potentially severe or even life-threatening immune-related toxicities, specifically cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). Consequently, medical emergency teams (MET) are increasingly involved in the assessment and management of CAR T‐cell recipients. This article describes the principles of CAR T‐cell therapy and summarizes the main complications and subsequent therapeutic interventions aiming to provide a survival guide for METs with a proposed management algorithm.
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Anna S. Messmer; Yok-Ai Que; Christoph Schankin; Yara Banz; Ulrike Bacher; Urban Novak; Thomas Pabst
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)