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MicroRNA profiles of human peripheral arteries and abdominal aorta in normal conditions: MicroRNAs-27a-5p, -139-5p and -155-5p emerge and in atheroma too by Salvatore Collura; Carmen Ciavarella; Cristina Morsiani; Ilenia Motta; Sabrina Valente; Enrico Gallitto; Mohammad Abualhin; Rodolfo Pini; Francesco Vasuri; Claudio Franceschi; Miriam Capri; Mauro Gargiulo; Gianandrea Pasquinelli is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is MicroRNA profiles of human peripheral arteries and abdominal aorta in normal conditions: MicroRNAs-27a-5p, -139-5p and -155-5p emerge and in atheroma too about?

Atherosclerosis may starts early in life and each artery has peculiar characteristics likely affecting atherogenesis. The primary objective of the work was to underpin the microRNA (miR)-profiling differences in human normal femoral, abdominal aortic, and carotid arteries. The secondary aim was to investigate if those identified miRs, differently expressed in normal conditions, may also have a role in atherosclerotic arteries at adult ages. MiRprofiles were performed on normal tissues, revealing that aorta and carotid arteries are more similar than femoral arteries. MiRs emerging from profiling comparisons, i.e., miR-155-5p, -27a-5p, and -139-5p, were subjected to validation by RT-qPCR in normal arteries and also in pathological/atheroma counterparts, considering all the available 20 artery specimens. The three miRs were confirmed to be differentially expressed in normal femoral vs aorta/carotid arteries. Differential expression of those miRs was also observed in atherosclerotic arteries, together with some miR-target proteins, such as vimentin, CD44, E-cadherin and an additional marker SLUG. The different expression of miRs and targets/markers suggests that aorta/carotid and femor

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Author

Salvatore Collura; Carmen Ciavarella; Cristina Morsiani; Ilenia Motta; Sabrina Valente; Enrico Gallitto; Mohammad Abualhin; Rodolfo Pini; Francesco Vasuri; Claudio Franceschi; Miriam Capri; Mauro Gargiulo; Gianandrea Pasquinelli

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)