Can I read Polymorphism of the Tumour Necrosis Factor‐alpha and Lymphotoxin‐alpha Genes in Hairy Cell Leukaemia on EtoBox?

Polymorphism of the Tumour Necrosis Factor‐alpha and Lymphotoxin‐alpha Genes in Hairy Cell Leukaemia by Judith Demeter; Franz Porzsolt; Stephanie RÄmisch; Mathias Schmid; Gerald Messer is a Medicine article available to read on EtoBox.

What is Polymorphism of the Tumour Necrosis Factor‐alpha and Lymphotoxin‐alpha Genes in Hairy Cell Leukaemia about?

Hairy cell leukaemia (HCL) is a rare chronic B lymphoproliferative disorder which can lead to severe pancytopenia and several immunologic abnormalities. The pathogenetic role of tumour necrosis factor (TNF)‐α in HCL prompted us to study the potential contribution of functionally important genetic polymorphisms of the TNF gene cluster in a large group of patients with HCL. The TNF‐α (−308 bp) promoter/enhancer point mutation and two polymorphisms located within the first intron of the lymphotoxin (LT)‐α gene showed neither significant allelic deviation for the patient group nor, after analysis of clinical characteristics such as blood counts, stable or progressive disease or response to therapy.

Who reads Polymorphism of the Tumour Necrosis Factor‐alpha and Lymphotoxin‐alpha Genes in Hairy Cell Leukaemia?

Author

Judith Demeter; Franz Porzsolt; Stephanie RÄmisch; Mathias Schmid; Gerald Messer

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)

Published

1997

Language

EN

Field

Medicine (Health Sciences)