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Elevated levels of biologically active soluble CD40 ligand in the serum of patients with chronic lymphocytic leukaemia by Anas Younes; Virginia Snell; Ugo Consoli; Katharina Clodi; Shourong Zhao; J. Lynn Palmer; Elaine K. Thomas; Richard J. Armitage; Michael Andreeff is a Medicine article available to read on EtoBox.

What is Elevated levels of biologically active soluble CD40 ligand in the serum of patients with chronic lymphocytic leukaemia about?

Chronic lymphocytic leukaemia (CLL) is an indolent lymphoproliferative disorder manifested by low growth fraction and prolonged survival of the malignant cells. The mechanisms that enable CLL cells to live longer and to resist apoptosis remain unclear. Because the malignant CLL cells express CD40 and Fas receptors, which can transduce cell‐survival and cell‐death signals, we examined the role of CD40 in the growth regulation of CLL cells and its interaction with Fas‐mediated and fludarabine‐induced apoptosis __in vitro__. Primary CLL cells underwent spontaneous apoptosis in culture, which was enhanced by exogenous human Fas ligand (FasL) or fludarabine. Exogenous CD40L rescued CLL cells from spontaneous apoptosis in a dose‐dependent manner, and caused CLL cells to resist apoptosis induced by FasL or fludarabine. Patients' autologous plasma rescued CLL cells from spontaneous apoptosis, an effect that could be reversed with anti‐CD40 ligand (CD40L) antibodies. The levels of soluble CD40 ligand in the sera of 51 CLL patients and 55 healthy donors were determined by enzyme‐linked immunosorbent assay. The mean soluble CD40L level in normal donors was 0.29 ng/ml compared to a mean value

Who reads Elevated levels of biologically active soluble CD40 ligand in the serum of patients with chronic lymphocytic leukaemia?

Author

Anas Younes; Virginia Snell; Ugo Consoli; Katharina Clodi; Shourong Zhao; J. Lynn Palmer; Elaine K. Thomas; Richard J. Armitage; Michael Andreeff

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)

Published

1998

Language

EN

Field

Medicine (Health Sciences)