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Acute Kidney Injury after CAR-T Cell Therapy: Low Incidence and Rapid Recovery by Gutgarts, Victoria; Jain, Tania; Zheng, Junting; Maloy, Molly A.; Ruiz, Josel D.; Pennisi, Martina; Jaimes, Edgar A.; Perales, Miguel-Angel; Sathick, Insara Jaffer is a Medicine article available to read on EtoBox.

What is Acute Kidney Injury after CAR-T Cell Therapy: Low Incidence and Rapid Recovery about?

Chimeric antigen receptor (CAR) T cell therapy using engineered cytotoxic T cells has shown promising responses in various hematologic malignancies. Cytokine release syndrome (CRS) and immune effector cell-associated neurologic syndrome (ICANS) are recognized toxicities of CAR-T, whereas kidney injury remains less well recognized. The objective of the present study was to identify the incidence of acute kidney injury (AKI) after CAR-T cell therapy, potential risk factors, and recovery of kidney function. We performed a retrospective review of 46 adult patients with non-Hodgkin lymphoma treated with CAR-T therapy between February 2018 and February 2019 at our institution. Serum creatinine values before CAR-T therapy through day 100 were used to assess AKI, as defined by the Kidney Disease Improving Global Outcomes (KDIGO) criteria: grade 1, 1.5- to <2-fold of baseline; grade 2, 2- to <3-fold of baseline; grade 3, ≥3-fold of baseline. CRS and ICANS were graded using the consensus criteria of the American Society of Transplantation and Cellular Therapy. The overall incidence of CRS was 78.3% (95% confidence interval [CI], 66% to 90.5%), of whom 13% (95% CI, 3.3% to 22.8%) developed gr

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Author

Gutgarts, Victoria; Jain, Tania; Zheng, Junting; Maloy, Molly A.; Ruiz, Josel D.; Pennisi, Martina; Jaimes, Edgar A.; Perales, Miguel-Angel; Sathick, Insara Jaffer

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1083-8791)

Published

2020

Language

EN

Field

Medicine (Health Sciences)