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No Difference in Markers of Adipose Tissue Inflammation Between Overweight Women with Polycystic Ovary Syndrome and Weight-matched Controls by A. Lindholm; C. Blomquist; M. Bixo; I. Dahlbom; T. Hansson; I. Sundstrom Poromaa; J. Buren is a Medicine article available to read on EtoBox.
What is No Difference in Markers of Adipose Tissue Inflammation Between Overweight Women with Polycystic Ovary Syndrome and Weight-matched Controls about?
## BACKGROUND Previous studies have indicated that peripheral circulating markers of inflammation are elevated in women with polycystic ovary syndrome (PCOS), but thus far no studies concerning markers of inflammation in adipose tissue have been published. The aim of the study was to investigate whether patients with PCOS display increased expression of inflammatory markers in adipose tissue. ## METHODS Twenty overweight patients with PCOS, 10 lean patients with PCOS and 20 overweight controls had subcutaneous fat biopsies and blood samples taken. Adipose tissue levels of mRNA of inflammatory markers were determined by use of real-time PCR. ## RESULTS Overweight patients with PCOS had higher relative adipose tissue chemokine ligand 2 (__P__ < 0.01), and its cognate receptor (__P__ < 0.05), tumour necrosis factor-α (__P__ < 0.001), interleukin (IL)-10 (__P__ < 0.001) and IL-18 (__P__ < 0.001) and the monocyte/macrophage markers CD14 (__P__ < 0.01) and CD163 (__P__ < 0.01) mRNA levels compared with lean women with PCOS. There were no differences between overweight patients with PCOS and overweight control subjects in this respect. Within the PCOS group, markers of adipose tissue infl
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- Author
- A. Lindholm; C. Blomquist; M. Bixo; I. Dahlbom; T. Hansson; I. Sundstrom Poromaa; J. Buren
- Publisher
- Oxford University Press (OUP)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)