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Transepithelial transport and cell volume control in proximal renal tubules from the teleost Carassius auratus by H. KANLI; D.A. TERREROS is a Medicine article available to read on EtoBox.

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The objective of this work was to study cell volume regulation and transepithelial transport in renal proximal tubules. A modified stop‐flow technique in __in vitro__ perfused renal proximal tubules of __Carassius auratus__ was used. The rate of luminal fluid absorption and the epithelial thickness were measured. Isosmotic Na^+^ removal from the tubule lumen or addition of the Na^+^/glucose co‐transport blocker phloridzin (0.5 mM) to the lumen inhibited fluid absorption. Only minor effects on luminal absorption were observed following: (1) addition of the K^+^ channel inhibitor BaCl~2~ (1 mM); (2) addition of the Cl^−^ channel inhibitor MK‐196 (1 mM); (3) lowering bath and perfusate HCO~3~^−^ in the presence of 0.1 mM acetazolamide; or (4) addition of the leukotriene‐D~4~ receptor antagonist L‐660, 711 (20 μM). Isosmotic addition of 40 mM taurine to the bath inhibited the rate of fluid absorption. This effect could be partially overcome with the organic acid secretion inhibitors probenecid (1 mM) and bromcresol green (0.1 mM). Finally, administration of the 5‐lipoxygenase antagonist ETH 615–139 (20 μM) caused a significant reduction in the rate of luminal absorption. In summary, tu

Who reads Transepithelial transport and cell volume control in proximal renal tubules from the teleost Carassius auratus?

Author

H. KANLI; D.A. TERREROS

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0001-6772)

Published

1997

Language

EN

Field

Medicine (Life Sciences)