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Why are epilepsy mortality rates rising in the United States? A population-based multiple cause-of-death study by Christopher M DeGiorgio; Ashley Curtis; Armen Carapetian; Dominic Hovsepian; Anusha Krishnadasan; Daniela Markovic is a Medicine article available to read on EtoBox.

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## Introduction Epilepsy mortality rates are rising. It is unknown whether rates are rising due to an increase in epilepsy prevalence, changes in epilepsy causes of death, increase in the lethality or epilepsy or failures of treatment. To address these questions, we compare epilepsy mortality rates in the USA with all-cause and all-neurological mortality for the years 1999 to 2017. ## Objectives To determine changes in US epilepsy mortality rates versus all-cause mortality, and to evaluate changes in the leading causes of death in people with epilepsy. ## Design Retrospective population-based multiple cause-of-death study. ## Primary outcome Change in age-adjusted epilepsy mortality rates compared with mortality rates for all-cause and all-neurological mortality. ## Secondary outcome Changes in the leading causes of death in epilepsy. ## Results From 1999 to 2017, epilepsy mortality rates in the USA increased 98.8%, from 5.83 per million in 1999 to 11.59 per million (95% CI 88.2%–110.0%), while all-cause mortality declined 16.4% from 8756.34 per million to 7319.17 per million (95% CI 16.3% to 16.6%). For the same period, all-neurological mortality increased 80.8% from 309.21 to 558

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Author

Christopher M DeGiorgio; Ashley Curtis; Armen Carapetian; Dominic Hovsepian; Anusha Krishnadasan; Daniela Markovic

Publisher

BMJ

Published

2020

Language

EN

Field

Medicine (Health Sciences)