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Chemotherapy pretreatment sensitizes solid tumor‐derived cell lines to Vα24^+^ NKT cell‐mediated cytotoxicity by Stephen R. Mattarollo; Tony Kenna; Mie Nieda; Andrew J. Nicol is a Medicine article available to read on EtoBox.

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## Abstract There is an increasing awareness of the therapeutic potential for combining immune‐based therapies with chemotherapy in the treatment of malignant diseases, but few published studies evaluate possible cytotoxic synergies between chemotherapy and cytotoxic immune cells. Human Vα24^+^/Vβ11^+^ NKT cells are being evaluated for use in cell‐based immunotherapy of malignancy because of their immune regulatory functions and potent cytotoxic potential. In this study, we evaluated the cytotoxicity of combinations of chemotherapy and NKT cells to determine whether there is a potential to combine these treatment modalities for human cancer therapy. The cytotoxicity of NKT cells was tested against solid‐tumor derived cell lines NCI‐H358, DLD‐1, HT‐29, DU‐145, TSU‐Pr1 and MDA‐MB231, with or without prior treatment of these target cells, with a range of chemotherapy agents. Low concentrations of chemotherapeutic agents led to sensitization of cell lines to NKT‐mediated cytotoxicity, with the greatest effect being observed for prostate cancer cells. Synergistic cytotoxicity occurred in an NKT cell in a dose‐dependent manner. Chemotherapy agents induced upregulation of cell surface TRA

Who reads Chemotherapy pretreatment sensitizes solid tumor‐derived cell lines to Vα24^+^ NKT cell‐mediated cytotoxicity?

Author

Stephen R. Mattarollo; Tony Kenna; Mie Nieda; Andrew J. Nicol

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2006

Language

EN

Field

Medicine (Health Sciences)