Can I read Synthesis of [^14^C]‐pargyline {N‐methyl‐N‐([1‐^14^C]‐propargyl)benzylamine} with the radioactive label on the propargyl group on EtoBox?

Synthesis of [^14^C]‐pargyline {N‐methyl‐N‐([1‐^14^C]‐propargyl)benzylamine} with the radioactive label on the propargyl group by David J. W. Goon; James A. Elberling; E. G. Demaster; Herbert T. Nagasawa is a Chemistry article available to read on EtoBox.

What is Synthesis of [^14^C]‐pargyline {N‐methyl‐N‐([1‐^14^C]‐propargyl)benzylamine} with the radioactive label on the propargyl group about?

## Abstract A one‐pot reaction scheme leading to ^14^C‐labeled pargyline (N‐methyl‐N‐ propargylbenzylamine) where in the radioactive label from [^14^C]‐formaldehyde is synthetically incorporated into the methylene group of the propargyl side chain is described. Thus, [^14^C]‐formaldehyde (aqueous solution) is condensed in solvent dioxane with N‐methyl‐benzylamine and mono‐trimethylsilylacetylene in the presence of cupric acetate dihydrate at elevated temperatures (85–86°) for 24 hrs. The Mannich condensation product is then desilylated and the radiolabeled pargyline is purified by partitioning in ether from acid and base followed by flash chromatography, and isolated as the hydrochloride. The radioactive yield is 58%. This method should be generally applicable for the incorporation of radioactive label into the propargyl methylene group of other drugs containing a propargyl side chain.

Who reads Synthesis of [^14^C]‐pargyline {N‐methyl‐N‐([1‐^14^C]‐propargyl)benzylamine} with the radioactive label on the propargyl group?

Author

David J. W. Goon; James A. Elberling; E. G. Demaster; Herbert T. Nagasawa

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-2135)

Published

1990

Language

EN

Field

Chemistry (Life Sciences)