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What is 190603-Metformin Inhibits Gluconeogenesis Via A Redox-Dependent about?

This study shows that metformin inhibits gluconeogenesis in a redox-dependent manner by increasing the cytosolic redox state independently of mitochondrial complex I inhibition or reductions in energy charge. Metformin decreased glucose production from lactate and glycerol but not from pyruvate or alanine, demonstrating regulation of gluconeogenesis by the cytosolic redox state.

Author

Felipe Robinson

Language

EN