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Molecular epidemiology of human adenovirus isolated from children hospitalized with acute respiratory infection in São Paulo, Brazil by Patrícia O. Moura; Adriana F. Roberto; Noely Hein; Evandro Baldacci; Sandra E. Vieira; Bernardo Ejzenberg; Priscila Perrini; Klaus E. Stewien; Edison L. Durigon; Dolores U. Mehnert; Charlotte M. Hársi is a Medicine article available to read on EtoBox.
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## Abstract In a study of acute respiratory disease, two collections of nasopharyngeal aspirates (NPA) were obtained from children hospitalized at the Pediatric Clinic of the University Hospital, São Paulo, in 1995 and 2000. Adenovirus was detected in 33 (8.2%) of 401 children followed. These viruses were isolated in HEp‐2, HEK‐293, or NCI‐H292 cells and serotyped by neutralization. The genome types were determined after restriction analyses of the genomic DNA extracted from infected cells. Nineteen isolates were characterized as __Human adenovirus B__, genome types HAdV‐3a, HAdV‐7h, and HAdV‐7h1; 11 as __Human adenovirus C__, genome types HAdV‐1D10, HAdV‐2D25, HAdV‐5D2, and HAdV‐6D3. Our findings show that species C adenoviruses present an endemic infection pattern, with co‐circulation of different serotypes and genome types; no new genomic variant was observed. Species B adenoviruses showed epidemic infection patterns, with shifts in the predominant genome type. The isolates from 1995 belong to genome type 7h, or the variant 7h1, with a clear substitution of the type 7b, prevalent in São Paulo for more then 10 years. In 2000, the variant 7h1 predominated and the emergence of the
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- Author
- Patrícia O. Moura; Adriana F. Roberto; Noely Hein; Evandro Baldacci; Sandra E. Vieira; Bernardo Ejzenberg; Priscila Perrini; Klaus E. Stewien; Edison L. Durigon; Dolores U. Mehnert; Charlotte M. Hársi
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0146-6615)
- Published
- 2006
- Language
- EN
- Field
- Medicine (Health Sciences)