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Simultaneous Electrochemical and Electrochemiluminescence Detection for Microchip and Conventional Capillary Electrophoresis by Haibo Qiu; Xue-Bo Yin; Jilin Yan; Xiaocui Zhao; Xiurong Yang; Erkang Wang is a Engineering article available to read on EtoBox.

What is Simultaneous Electrochemical and Electrochemiluminescence Detection for Microchip and Conventional Capillary Electrophoresis about?

A simultaneous electrochemical (EC) and electrochemiluminescence (ECL) detection scheme was introduced to both microchip and conventional capillary electrophoresis (CE). In this dual detection scheme, tris(2,2'-bipyridyl)ruthenium(II) (Ru(bpy)3(2+)) was used as an ECL reagent as well as a catalyst (in the formation of Ru(bpy)3(3+)) for the EC detection. In the Ru(bpy)3(2+)-ECL process, Ru(bpy)3(3+) was generated and then reacted with analytes resulting in an ECL emission and a great current enhancement in EC detection due to the catalysis of Ru(bpy)3(3+). The current response and ECL signals were monitored simultaneously. In the experiments, dopamine and three kinds of pharmaceuticals, anisodamine, ofloxacin, and lidocaine, were selected to validate this dual detection strategy. Typically, for the EC detection of dopamine with the presence of Ru(bpy)3(2+), a approximately 5 times higher signal-to-noise ratio (S/N) can be achieved than that without Ru(bpy)3(2+), during the simultaneous EC and ECL detection of a mixture of dopamine and lidocaine using CE separation. The results indicated that this dual EC and ECL detection strategy could provide a simple and convenient detection meth

Who reads Simultaneous Electrochemical and Electrochemiluminescence Detection for Microchip and Conventional Capillary Electrophoresis?

Author

Haibo Qiu; Xue-Bo Yin; Jilin Yan; Xiaocui Zhao; Xiurong Yang; Erkang Wang

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 0173-0835)

Published

2005

Language

EN

Field

Engineering (Physical Sciences)