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Peroxidation of LDL From Combined-Hyperlipidemic Male Smokers Supplied With ̄-3 Fatty Acids and Antioxidants by Brude, Ingeborg R.; Drevon, Christian A.; Hjermann, Ingvar; Seljeflot, Ingebjà ̧rg; Lund-Katz, Sissel; Saarem, Kristin; Sandstad, Berit; Solvoll, Kari; Halvorsen, Bente; Arnesen, Harald; Nenseter, Mari is a Medicine article available to read on EtoBox.

What is Peroxidation of LDL From Combined-Hyperlipidemic Male Smokers Supplied With ̄-3 Fatty Acids and Antioxidants about?

The effects of marine omega-3 polyunsaturated fatty acids (FAs) and antioxidants on the oxidative modification of LDL were studied in a randomized, double-blind, placebo-controlled trial. Male smokers (n = 41) with combined hyperlipidemia were allocated to one of four groups receiving supplementation with omega-3 FAs (5 g eicosapentaenoic acid and docosahexaenoic acid per day), antioxidants (75 mg vitamin E, 150 mg vitamin C, 15 mg beta-carotene, and 30 mg coenzyme Q10 per day), both omega-3 FAs and antioxidants, or control oils. LDL and human mononuclear cells were isolated from the patients at baseline and after 6 weeks of supplementation. LDL was subjected to cell-mediated oxidation by the patients' own mononuclear cells, as well as to Cu(2+)-catalyzed and 2,2'-azobis-(2-amidinopropane hydrochloride) (AAPH)-initiated oxidation. Extent of LDL modification was measured as lag time, the formation rate of conjugated dienes (CDs), the maximum amount of CDs formed, formation of lipid peroxides, and the relative electrophoretic mobility of LDL on agarose gels. Dietary supplementation with omega-3 FAs increased the concentration of total omega-3 FAs in LDL and reduced the concentration

Who reads Peroxidation of LDL From Combined-Hyperlipidemic Male Smokers Supplied With ̄-3 Fatty Acids and Antioxidants?

Author

Brude, Ingeborg R.; Drevon, Christian A.; Hjermann, Ingvar; Seljeflot, Ingebjà ̧rg; Lund-Katz, Sissel; Saarem, Kristin; Sandstad, Berit; Solvoll, Kari; Halvorsen, Bente; Arnesen, Harald; Nenseter, Mari

Publisher

Lippincott Williams and Wilkins; Ovid Technologies Wolters Kluwer -American Heart Association; Lippincott Williams & Wilkins Ltd.; Ovid Technologies (Wolters Kluwer Health) (ISSN 1079-5642)

Published

1997

Language

EN

Field

Medicine (Health Sciences)