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THU499 The Mesenchymal Stem Cells Induce Immunosuppressive Microenvironment In Pituitary Tumors by Daniel Marrero-Rodríguez; Victor A Cortes-Morales; Keiko Taniguchi-Ponciano; Alejandra Valenzuela-Perez; Sandra Vela-Patiño; Amayrani Cano-Zaragoza; Florencia Martinez-Mendoza; Jacobo Kerbel; Sergio Andonegui-Elguera; Juan Jose Montesinos; Moises Mercado is a Medicine article available to read on EtoBox.

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## Abstract **Disclosure: D. Marrero-Rodríguez:** None. **V. Cortes-Morales:** None. **K. Taniguchi-Ponciano:** None. **A. Valenzuela-Perez:** None. **S. Vela-Patiño:** None. **A. Cano-Zaragoza:** None. **F. Martinez-Mendoza:** None. **J. Kerbel:** None. **S. Andonegui-Elguera:** None. **J. Montesinos:** None. **M. Mercado:** None. The tumor microenvironment (TME) includes diverse cellular components such as mesenchymal stem cells (MSC) and immune cells. MSC are a subset of heterogeneous cell populations characterized by the expression of CD105, CD73, and CD90 that can differentiate into chondrocytes, osteoblasts, and adipocytes __in vitro__. They are known to have immunomodulatory capabilities. Our aim was to isolate and characterize the immunomodulatory capabilities of MSC from pituitary tumors (PT) and non-tumoral gland as well as to describe the immune TME. We isolated and cultivated MSC from LH/FSH-PT and ACTH-PT, as well as non-tumoral pituitary glands. The MSC obtained from PT and non-tumoral gland were co-cultured in the presence of monocytes from healthy donors and their ability to transform into M0, M1 or M2 macrophages was assessed by flow cytometry. The results showed t

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Author

Daniel Marrero-Rodríguez; Victor A Cortes-Morales; Keiko Taniguchi-Ponciano; Alejandra Valenzuela-Perez; Sandra Vela-Patiño; Amayrani Cano-Zaragoza; Florencia Martinez-Mendoza; Jacobo Kerbel; Sergio Andonegui-Elguera; Juan Jose Montesinos; Moises Mercado

Publisher

The Endocrine Society

Published

2023

Field

Medicine (Health Sciences)