Can I read PEGylated polylysine derived copolymers with reduction‐responsive side chains for anticancer drug delivery on EtoBox?

PEGylated polylysine derived copolymers with reduction‐responsive side chains for anticancer drug delivery by Jiuxu Yao; Pan He; Yu Zhang; Hongyu Zhang; Peng Zhang; Mingxiao Deng; Chunsheng Xiao is a Materials Science article available to read on EtoBox.

What is PEGylated polylysine derived copolymers with reduction‐responsive side chains for anticancer drug delivery about?

## Abstract Reduction‐responsive drug delivery systems have recently gained intense attention in intracellular delivery of anticancer drugs. In this study, we developed a PEGylated polypeptide, poly(ethylene glycol)‐__block__‐poly(ε‐propargyloxycarbonyl‐l‐lysine) (PEG~113~‐__b__‐PPAL), as a novel clickable substrate for conjugation of reduction‐responsive side chains for antineoplastic drug delivery. PEG~113~‐__b__‐PPAL was synthesized through ring‐opening polymerization of alkyne‐containing __N__‐carboxyanhydride monomers. A designed disulfide‐containing side chain was introduced onto the PEGylated polypeptide by click reaction. The obtained copolymer PEG~113~‐__b__‐P(Lys‐DSA) formed micelles by self‐assembly, which exhibited reduction‐responsive behavior under the stimulus of 10 mmol L^–1^ glutathione (GSH) in water. A small molecule intermediate, compound 2, was used as a model to investigate the thiol reduction mechanism of PEG~113~‐__b__‐P(Lys‐DSA) copolymers. The anticancer drug doxorubicin (DOX) was then loaded into the micelles with a drug loading content of 6.73 wt% and a loading efficiency of 40.3%. Both the blank and the drug‐loaded micelles (DOX‐loaded polylysine derive

Who reads PEGylated polylysine derived copolymers with reduction‐responsive side chains for anticancer drug delivery?

Author

Jiuxu Yao; Pan He; Yu Zhang; Hongyu Zhang; Peng Zhang; Mingxiao Deng; Chunsheng Xiao

Publisher

Wiley

Published

2019

Language

EN

Field

Materials Science (Physical Sciences)