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Mesangial factor V expression colocalized with fibrin deposition in IgA nephropathy by Ning Liu; Takahiko Ono; Katsuo Suyama; Fumiaki Nogaki; Kiichi Shirakawa; Mari Maeda; Takahide Kawamura; Tadashi Kamata; Atsushi Oyama; Eri Muso; Shigetake Sasayama is a Medicine article available to read on EtoBox.
What is Mesangial factor V expression colocalized with fibrin deposition in IgA nephropathy about?
## Background: Factor v in its active form (va) plays a key role at the termination of the intrinsic coagulation pathway, serving as a membrane-bound cofactor for the conversion of prothrombin to thrombin by factor xa. cross-linked fibrin (xfb) is often observed in mesangial areas in active types of human glomerulonephritis. in this study, to clarify contribution of factor v in intramesangial coagulation, mesangial factor v expression and its relationship to mesangial proliferation and fibrin deposition in iga nephropathy (igan) were investigated. ## Methods: Twenty-two patients with igan were studied. xfb was detected in renal biopsy specimens using anti-d-dimer antibody combined with plasmin exposure, and factor v was detected with rabbit antibody against human factor v. double-labeling immunohistochemistry was used to investigate the relationship of the glomerular distribution of factor v to xfb. the relationship of factor v staining to the activity index or xfb deposition was evaluated. the expression of factor v mrna was assessed by in situ hybridization in relationship to the antigen staining of alpha-smooth muscle actin (alpha-sma). the ultrastructural distribution of factor
Who reads Mesangial factor V expression colocalized with fibrin deposition in IgA nephropathy?
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- Author
- Ning Liu; Takahiko Ono; Katsuo Suyama; Fumiaki Nogaki; Kiichi Shirakawa; Mari Maeda; Takahide Kawamura; Tadashi Kamata; Atsushi Oyama; Eri Muso; Shigetake Sasayama
- Publisher
- Nature Publishing Group; Elsevier ; Elsevier Inc.; Elsevier BV; ScienceOpen (ISSN 0085-2538)
- Published
- 2000
- Language
- EN
- Field
- Medicine (Health Sciences)