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Capsaicin as a source for painful stimulation in functional MRI by Krisztina L. Malisza; John C. Docherty is a Medicine article available to read on EtoBox.
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## Abstract Functional magnetic resonance imaging (fMRI) was used to examine the brain processing of capsaicin‐induced painful stimulation in the α‐chloralose anesthetized rat. Experiments were performed on a 9.4‐T magnet (Magnex, UK) with Avance console (Bruker, Germany) using a surface coil tuned to 400.5 MHz centred over the rat forebrain. Gradient‐echo images of two slices, with an echo time of 25 msec, repetition time of 70 msec, and 50 repetitions, were acquired per experiment. These images were analyzed using a fuzzy cluster analysis technique (EvIdentTM). Activation of areas of the brain known to be associated with the processing of pain, namely the anterior cingulate (bilateral), frontal cortex (bilateral), and sensory motor cortex (contralateral), was found in all animals (__N__ = 6) following injection of 25μL of capsaicin (128μg/mL in 7.5% dimethylsulfoxide [DMSO]) into the dorsal forepaw. It is possible to reproduce the pain response in a given animal several times throughout the course of an experiment, provided that sufficient time is allowed between capsaicin injections. This acute phase of capsaicin‐induced pain involving stimulation of C polymodal nociceptors was
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- Author
- Krisztina L. Malisza; John C. Docherty
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1053-1807)
- Published
- 2001
- Language
- EN
- Field
- Medicine (Health Sciences)