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Isochoric Supercooling Organ Preservation System by Gabriel Năstase; Florin Botea; George-Andrei Beșchea; Ștefan-Ioan Câmpean; Alexandru Barcu; Ion Neacșu; Vlad Herlea; Irinel Popescu; Tammy T. Chang; Boris Rubinsky; Alexandru Șerban is a Medicine article available to read on EtoBox.

What is Isochoric Supercooling Organ Preservation System about?

This technical paper introduces a novel organ preservation system based on isochoric (constant volume) supercooling. The system is designed to enhance the stability of the metastable supercooling state, offering potential long-term preservation of large biological organs at subfreezing temperatures without the need for cryoprotectant additives. Detailed technical designs and usage protocols are provided for researchers interested in exploring this field. The paper also presents a control system based on the thermodynamics of isochoric freezing, utilizing pressure monitoring for process control. Sham experiments were performed using whole pig liver sourced from a local food supplier to evaluate the system’s ability to sustain supercooling without ice nucleation for extended periods. The results demonstrated sustained supercooling without ice nucleation in pig liver tissue for 24 and 48 h. These findings suggest the potential of this technology for large-volume, cryoprotectant-free organ preservation with real-time control over the preservation process. The simplicity of the isochoric supercooling device and the design details provided in the paper are expected to serve as encouragem

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Author

Gabriel Năstase; Florin Botea; George-Andrei Beșchea; Ștefan-Ioan Câmpean; Alexandru Barcu; Ion Neacșu; Vlad Herlea; Irinel Popescu; Tammy T. Chang; Boris Rubinsky; Alexandru Șerban

Publisher

MDPI AG

Published

2023

Language

EN

Field

Medicine (Health Sciences)