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Systematic Review: Molecular Studies of Common Genetic Variation in Child and Adolescent Psychiatric Disorders by Wonuola A. Akingbuwa; Anke R. Hammerschlag; Meike Bartels; Christel M. Middeldorp is a Psychology article available to read on EtoBox.

What is Systematic Review: Molecular Studies of Common Genetic Variation in Child and Adolescent Psychiatric Disorders about?

## Objective: A systematic review of studies using molecular genetics and statistical approaches to investigate the role of common genetic variation in the development, persistence, and comorbidity of childhood psychiatric traits was conducted. ## Method: A literature review was performed using the pubmed database, following prisma guidelines. there were 131 studies meeting inclusion criteria, having investigated at least one type of childhood-onset or childhood-measured psychiatric disorder or trait with the aim of identifying trait-associated common genetic variants, estimating the contribution of single nucleotide polymorphisms (snps) to the amount of variance explained (snp-based heritability), investigating genetic overlap between psychiatric traits, or investigating whether the stability in traits or the association with adult traits is explained by genetic factors. ## Results: The first robustly associated genetic variants have started to be identified for childhood psychiatric traits. there were substantial contributions of common genetic variants to many traits, with variation in single nucleotide polymorphism heritability estimates depending on age and raters. moreover, g

Who reads Systematic Review: Molecular Studies of Common Genetic Variation in Child and Adolescent Psychiatric Disorders?

Author

Wonuola A. Akingbuwa; Anke R. Hammerschlag; Meike Bartels; Christel M. Middeldorp

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Psychology (Social Sciences)