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Can I read Treatment with Sulfasalazine or Sulfapyridine, but Not 5-Aminosalicyclic Acid, Inhibits Basic Fibroblast Growth Factor-induced Endothelial Cell Chemotaxis on EtoBox?
Treatment with Sulfasalazine or Sulfapyridine, but Not 5-Aminosalicyclic Acid, Inhibits Basic Fibroblast Growth Factor-induced Endothelial Cell Chemotaxis by Michael V. Volin; Lisa A. Harlow; James M. Woods; Phillip L. Campbell; M. Asif Amin; Michihide Tokuhira; Alisa E. Koch is a Medicine article available to read on EtoBox.
What is Treatment with Sulfasalazine or Sulfapyridine, but Not 5-Aminosalicyclic Acid, Inhibits Basic Fibroblast Growth Factor-induced Endothelial Cell Chemotaxis about?
## Objective: Rheumatoid arthritis (ra) is characterized by leukocyte recruitment and angiogenesis. we investigated the effects of sulfasalazine (ssz) and its metabolites, sulfapyridine (sp) and 5-aminosalicylic acid (5-asa), on components of angiogenesis, namely, endothelial cell (ec) chemotaxis and proliferation, as well as on ec chemokine and soluble adhesion molecule expression. ## Methods: Ssz, sp, and 5-asa were assayed for their effects on basic fibroblast growth factor (bfgf)-induced human dermal microvascular endothelial cell (hmvec) chemotaxis and proliferation. ec were plated on matrigel to assess the effect of ssz on ec tube formation. enzyme-linked immunosorbent assays were performed to determine changes in hmvec production of interleukin-8 (il-8), monocyte chemoattractant protein-1 (mcp-1), growth-related oncogene alpha (groalpha), epithelial neutrophil-activating peptide 78 (ena-78), soluble e-selectin (se-selectin), and soluble intercellular adhesion molecule 1 (sicam-1) upon treatment with ssz or its metabolites. ## Results: Hmvec incubated with ssz or sp exhibited reduced bfgf-induced chemotaxis (59%, [n = 7] and 22%, [n = 3], respectively) (p<0.05). ssz and sp de
Who reads Treatment with Sulfasalazine or Sulfapyridine, but Not 5-Aminosalicyclic Acid, Inhibits Basic Fibroblast Growth Factor-induced Endothelial Cell Chemotaxis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Michael V. Volin; Lisa A. Harlow; James M. Woods; Phillip L. Campbell; M. Asif Amin; Michihide Tokuhira; Alisa E. Koch
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0004-3591)
- Published
- 1999
- Language
- EN
- Field
- Medicine (Health Sciences)