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What is 3-Day Caco-2 Model for Drug Permeation about?
This study introduces a rapid 3-day Caco-2 monolayer system for assessing the intestinal permeability of therapeutic polypeptides, specifically insulin, calcitonin, and exenatide. The results indicate that the permeability values obtained from the 3-day cultures are more closely aligned with ex vivo models compared to conventional 21-day cultures. This new approach offers a high-throughput and reproducible method for screening oral absorption of macromolecules, addressing limitations of traditional models.
- Author
- nada44basher
- Language
- EN