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Heterogeneity of Es-1 esterases in the rabbit (Oryctolagus cuniculus) by H. Bellen; A. Van de Weghe; Y. Bouquet; L. F. M. Van Zutphen is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Heterogeneity of Es-1 esterases in the rabbit (Oryctolagus cuniculus) about?

Analysis of the Es-1 system in the rabbit with polyacrylamide gel electrophoresis (PAGE) revealed a high degree of individual variation. In the liver the number of esterase bands found in the Es-1 region of the gels ranged from 2 to 16. The results indicate that one locus with three alleles is responsible for all of the esterase bands in the Es-1 region. The most plausible explanation for the observed heterogeneity is that each of the alleles codes for a protein (MW 65,000 +\_ 2000) that is changed by posttranslational modifications, thus giving rise to two to five monomeric enzymes with esterase activity. Polymerization of these monomers then results in 1-11 dimers. Based on similarities with mouse Es-9, chromosomal homology between rabbit Es-1 and mouse Es-9 is proposed.

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Author

H. Bellen; A. Van de Weghe; Y. Bouquet; L. F. M. Van Zutphen

Publisher

Springer; Springer-Verlag; Kluwer Academic/Plenum Publishers; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0006-2928)

Published

1984

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)