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Can I read The Role of Liquid Rheological Properties on the Injection Process of a Spring-driven Autoinjector on EtoBox?
The Role of Liquid Rheological Properties on the Injection Process of a Spring-driven Autoinjector by Xiaoxu Zhong; Harsa Mitra; Jean-Christophe Veilleux; Emma Simmons; Galen Huaiqiu Shi; Arezoo M. Ardekani is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.
What is The Role of Liquid Rheological Properties on the Injection Process of a Spring-driven Autoinjector about?
Accurate injection time prediction is essential in developing spring-driven autoinjector devices since the drug delivery is expected to finish within seconds to bring convenience, reduce the risk for early lift-off, and provide a consistent experience to users. The Carreau model captures the liquid's shear-dependent viscosity measured in our experiments. Thus, a quasi-steady model, which uses the Carreau model to describe the liquid's viscosity, is developed to predict the injection time of spring-driven autoinjectors. Analytical relations between the flow rate and the pressure drop in the needle are also obtained. The Carreau number in the springdriven autoinjector is greater than one and smaller than a critical value; in this region, using the power-law model to describe the liquid viscosity accurately predicts the injection time, which agrees with the current literature findings. Additionally, a force threshold is identified for the friction force between the plunger and the syringe barrel, beyond which the injection time is infinite. Appreciation of this force threshold can help avoid device stalling and reduce the risk of underdosing. Moreover, the role of liquid's shear-thinn
Who reads The Role of Liquid Rheological Properties on the Injection Process of a Spring-driven Autoinjector?
It is typically read by researchers, students, and practitioners in Pharmacology, Toxicology and Pharmaceutics.
- Author
- Xiaoxu Zhong; Harsa Mitra; Jean-Christophe Veilleux; Emma Simmons; Galen Huaiqiu Shi; Arezoo M. Ardekani
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Pharmacology, Toxicology and Pharmaceutics (Life Sciences)