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Verteporfin synergizes the efficacy of anti-PD-1 in cholangiocarcinoma by Jianyang Fu; Nicole A McGrath; Jihye Lee; Xin Wang; Gagandeep Brar; Changqing Xie is a Medicine article available to read on EtoBox.

What is Verteporfin synergizes the efficacy of anti-PD-1 in cholangiocarcinoma about?

## Background: Cholangiocarcinoma (cca) is one of the primary hepatobiliary malignant neoplasms with only 10% of 5-year survival rate. promising immunotherapy with the blockade of immune checkpoints has no clear benefit in cca. the inhibition of yap1 signaling by verteporfin has shown encouraging results by inhibiting cell proliferation and inducing apoptosis. this study aimed to evaluate the potential benefit of the combination of verteporfin and anti-programmed cell death 1 (pd-1) in cca mouse model. ## Methods: We assessed the cytotoxicity of verteporfin in human cca cell lines in vitro, including both intrahepatic cca and extrahepatic cca cells. we examined the in vitro effect of verteporfin on cell proliferation, apoptosis, and stemness. we evaluated the in vivo efficacy of verteporfin, anti-pd-1, and a combination of both in subcutaneous cca mouse model. ## Results: Our study showed that verteporfin reduced tumor cell growth and enhanced apoptosis of human cca tumor cells in vitro in a dose-dependent fashion. nevertheless, verteporfin impaired stemness evidenced by reduced spheroid formation and colony formation, decreased numbers of cells with aldehyde dehydrogenase activity

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Author

Jianyang Fu; Nicole A McGrath; Jihye Lee; Xin Wang; Gagandeep Brar; Changqing Xie

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Medicine (Health Sciences)