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The study investigates the protective effect of the Dantu blood group variant against severe malaria, revealing that it provides significant resistance to Plasmodium falciparum invasion of red blood cells (RBCs) through increased membrane tension. Dantu RBCs exhibit extensive changes in surface protein composition, including reduced expression of the invasion receptor GYPA, which correlates with higher RBC tension that inhibits merozoite invasion. The findings suggest that the Dantu polymorphism offers insi

Author
cihansevgili6
Language
EN