Can I read Novel tetracyclic imidazole derivatives: Synthesis, dynamic NMR study, and anti‐inflammatory evaluation on EtoBox?

Novel tetracyclic imidazole derivatives: Synthesis, dynamic NMR study, and anti‐inflammatory evaluation by Renata Rupčić; Marina Modrić; Antun Hutinec; Ana Čikoš; Barbara Stanić; Milan Mesić; Dijana Pešić; Mladen Merćep is a Chemistry article available to read on EtoBox.

What is Novel tetracyclic imidazole derivatives: Synthesis, dynamic NMR study, and anti‐inflammatory evaluation about?

## Abstract magnified image A series of tetracyclic imidazole derivatives **9a**, **9b**, **9c**, **9d**, **9e**, **9f**, **9g**, **9h**, **9i**, **9j**, **9k**, **9l**, **9m**, **9n**, **9o**, **9p**, **9r**, **9s**, **9t**, **9v** and **10a**, **10b**, **10c**, **10d**, **10e**, **10f**, **10g**, **10h** are prepared by multistep route starting from the known tricyclic diketones **2a**, **2b**, **2c**, **2d**. Intermediary dibenzooxepin[4,5‐__d__]imidazoles (**3a**, **3c**) and dibenzothiepin[4,5‐__d__]imidazoles (**3b**, **3d**) are __N__‐protected to **4e****,** **4f** and to the isomeric compounds **5a**, **5b** and **6a**, **6b**. The isomeric compounds **5** and **6** are separated. Compounds **4**, **5,** and **6** are formylated at C(2) to afford **7a**, **7b**, **7c**, **7d**, **7e**, **7f**, **7g**, **7h**, **7i**, **7j**. In the last steps, aldehyde group is reduced, then alkylated to the two sets of isomeric ω‐dimethylaminoalkyl derivatives **9a**, **9b**, **9c**, **9d**, **9e**, **9f**, **9g**, **9h**, **9i**, **9j**, **9k**, **9l**, **9m**, **9n**, **9o**, **9p**, **9r**, **9s**, **9t**, **9v**. __N__‐deprotection of **9i–9v** led to the compounds **10a**, **10b**, *

Who reads Novel tetracyclic imidazole derivatives: Synthesis, dynamic NMR study, and anti‐inflammatory evaluation?

Author

Renata Rupčić; Marina Modrić; Antun Hutinec; Ana Čikoš; Barbara Stanić; Milan Mesić; Dijana Pešić; Mladen Merćep

Publisher

Journal of Heterocyclic Chemistry; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley; FASEB (ISSN 0022-152X)

Published

2010

Language

EN

Field

Chemistry (Physical Sciences)