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Research Progress of α-Synuclein Aggregation Inhibitors for Potential Parkinson’s Disease Treatment by Iqra Kalsoom; Yuanhao Wang; Bo Li; Hongliang Wen is a Chemistry article available to read on EtoBox.

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## Introduction: Parkinson’s disease (PD) is characterized by fibrillation of disordered proteins known as Lewy bodies in the substantia nigra that also undergo progressive neurodegeneration. The aggregation of α-synuclein (α-syn) is a hallmark and potentially a critical step in the development of Parkinson’s disease and other synucleinopathies. The synaptic vesicle protein α-syn is a small, abundant, highly conserved disordered protein and the causative agent of neurodegenerative diseases. Several novel pharmacologically active compounds are used to treat PD and other neurodegenerative disorders. Though, the mechanism through which these molecules inhibit the α-syn aggregation is still not fully understood. ## Objective: This review article is focused on the recent advancements in compounds that can inhibit the development of α-syn fibrillation and oligomerization. ## Methods: The current review article is based on the most recent and frequently cited papers from Google Scholar, SciFinder, and Researchgate sources. ## Description: In the progression of PD, the mechanism of α-syn aggregation involves the structural transformation from monomers into amyloid fibrils. As the accumulat

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Author

Iqra Kalsoom; Yuanhao Wang; Bo Li; Hongliang Wen

Publisher

Bentham Science Publishers Ltd.

Published

2023

Language

EN

Field

Chemistry (Physical Sciences)