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The assessment of a possible link between HPV‐mediated inflammation, apoptosis, and angiogenesis in Prostate cancer by Sadri Nahand, Javid; Esghaei, Maryam; Hamidreza Monavari, Seyed; Moghoofei, Mohsen; Jalal Kiani, Seyed; Mostafaei, Shayan; Mirzaei, Hamed; Bokharaei-Salim, Farah is a Immunology and Microbiology article available to read on EtoBox.
What is The assessment of a possible link between HPV‐mediated inflammation, apoptosis, and angiogenesis in Prostate cancer about?
## Background: The aim of this study was to determine the presence of HPV in patients with Prostate cancer (PCa) and its possible association with cancer progression. Methods: In this case-control study, fresh prostate tissues and blood samples were collected from 90 individuals, including 58 cases samples with PCa and 32 non-malignant prostate tissue samples as a control group. The expression level of viral genes (E2, E6, and E7) and cellular factors including tumor suppressor proteins (Rb and p53), anti-apoptotic mediators (Bcl-2 and survivin), and some mediators involved in inflammation and angiogenesis was evaluated. Results: The presence of the HPV genome was identified in 19 out of the 58 cases (32.7%) and five out of the 32 controls (15.6%). However, there was not any statistically significant relationship between the presence of the HPV genome and PCa (OR = 2.63, 95% C.I = 0.89-7.91, P-value = 0.078). Moreover, the HPV high-risk genotypes 16 and 18 were detected in 47.4% and 31.6% of HPV-infected PCa tissues, respectively. The expression level of the tumor suppressor proteins (Rb and p53) significantly decreased in the HPV-infected samples compared to the HPV negative speci
Who reads The assessment of a possible link between HPV‐mediated inflammation, apoptosis, and angiogenesis in Prostate cancer?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Sadri Nahand, Javid; Esghaei, Maryam; Hamidreza Monavari, Seyed; Moghoofei, Mohsen; Jalal Kiani, Seyed; Mostafaei, Shayan; Mirzaei, Hamed; Bokharaei-Salim, Farah
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 1567-5769)
- Published
- 2020
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)