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Inhibition of Staphylococcus aureus TetK and MsrA efflux pumps by hydroxyamines derived from lapachol and norlachol by Fernando Gomes Figueredo; Rodrigo Emmanuel L. T. Parente; Maynara Rodrigues Cavalcante-Figueredo; Jakson Gomes Figueiredo; Raimundo Luiz Pereira da Silva; Edinardo Fagner Ferreira Matias; Tania Maria Sarmento Silva; Celso Amorim Camara; Cícera Datiane de Morais Oliveira-Tintino; Saulo Relison Tintino; Henrique Douglas Melo Coutinho; Marta Maria de Franca Fonteles is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Inhibition of Staphylococcus aureus TetK and MsrA efflux pumps by hydroxyamines derived from lapachol and norlachol about?
The present study aimed to evaluate the in vitro efflux pump inhibitory capacity of hydroxyamines derived from lapachol and norlachol, where compounds 3, 4, and 5 were tested against the S. aureus strains: RN4220 carrying the pUL5054 plasmid; and IS-58, endowed with the PT181 plasmid. The substances were synthesized from 2-hydroxy-quinones, lapachol and nor-lapachol obtaining the corresponding 2-methoxylated derivatives via dimethyl sulfate alkylation in a basic medium, which then reacted chemoselectively with 2-ethanolamine and 3-propanolamine to form the corresponding amino alcohols. The antibacterial action of the substances was quantified by determining the Minimum Inhibitory Concentration (MIC), while a microdilution assay was carried out to ascertain efflux pump inhibition of Staphylococcus aureus strains carrying the MsrA macrolide and the TetK tetracycline efflux pumps with the substances at a sub-inhibitory concentration. The results were subjected to statistical analysis by an ANOVA test and Bonferroni post hoc test. The MIC from the substances exhibited a value ≥ 1024 μg/mL. However, a significant reduction (p < 0.0001) of the erythromycin, tetracycline and ethidium brom
Who reads Inhibition of Staphylococcus aureus TetK and MsrA efflux pumps by hydroxyamines derived from lapachol and norlachol?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Fernando Gomes Figueredo; Rodrigo Emmanuel L. T. Parente; Maynara Rodrigues Cavalcante-Figueredo; Jakson Gomes Figueiredo; Raimundo Luiz Pereira da Silva; Edinardo Fagner Ferreira Matias; Tania Maria Sarmento Silva; Celso Amorim Camara; Cícera Datiane de Morais Oliveira-Tintino; Saulo Relison Tintino; Henrique Douglas Melo Coutinho; Marta Maria de Franca Fonteles
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)