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Using prescription claims data for drugs available over‐the‐counter (OTC) by Marianne Ulcickas Yood; Ulka B. Campbell; Kenneth J. Rothman; Susan S. Jick; Janet Lang; Karen E. Wells; Hershel Jick; Christine C. Johnson is a Medicine article available to read on EtoBox.
What is Using prescription claims data for drugs available over‐the‐counter (OTC) about?
## Abstract ## Purpose Many pharmacoepidemiologic studies use automated prescription claims data to estimate the association between exposure and disease. One limitation of automated data, when studying drugs that are also available via retail, is that over‐the‐counter (OTC) exposure is missed. The purpose of this study is to quantify the effect of misclassification of OTC use in research that uses prescription claims data as the sole source of exposure information. ## Methods We conducted a sensitivity analysis in the context of studies of non‐steroidal anti‐inflammatory drugs (NSAIDs) and colorectal cancer. The following factors were widely varied to examine the impact on the validity of the effect estimate for NSAIDs and colorectal cancer: (1) the overall prevalence of NSAID exposure in the population, (2) the proportion of NSAID exposure due to OTC use (the prevalence of missed NSAID exposure in studies of prescription claims), and (3) the true risk ratio (RR~true~). We graphed the RR that would be observed (RR~observed~) as a function of overall prevalence of NSAID use and the prevalence of NSAID use that is OTC exposure. ## Results We found that when the true RR ranges from 0
Who reads Using prescription claims data for drugs available over‐the‐counter (OTC)?
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- Author
- Marianne Ulcickas Yood; Ulka B. Campbell; Kenneth J. Rothman; Susan S. Jick; Janet Lang; Karen E. Wells; Hershel Jick; Christine C. Johnson
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1053-8569)
- Published
- 2007
- Language
- EN
- Field
- Medicine (Health Sciences)