Can I read Differing Effects of Endogenous and Synthetic Inhibitors of Metalloproteinases on Intestinal Tumorigenesis on EtoBox?

Differing Effects of Endogenous and Synthetic Inhibitors of Metalloproteinases on Intestinal Tumorigenesis by Kathleen J. Heppner Goss; Peter D. Brown; Lynn M. Matrisian is a Medicine article available to read on EtoBox.

What is Differing Effects of Endogenous and Synthetic Inhibitors of Metalloproteinases on Intestinal Tumorigenesis about?

Matrix metalloproteinase (MMP) activity has been associated with tumor invasion and metastasis in many different tumor types, but recent studies also support a role for these enzymes in earlier stages of the tumor progression continuum. Specifically, the expression pattern of MMPs in benign human and mouse gastrointestinal tumors suggests that they may function in the development or growth of non-invasive tumors. To address the contribution of MMP activity to the development of intestinal adenomas, we administered the synthetic MMP inhibitor batimastat and expressed the tissue inhibitor of metalloproteinases-1 (TIMP-1) in the gastrointestinal tract of Min mice, which spontaneously develop pre-malignant small and large intestinal tumors. Batimastat administration resulted in a 48% decrease in the number of Min tumors. This reduction in tumor number is similar to that observed in mice lacking the metalloproteinase matrilysin, and demonstrates the therapeutic and chemopreventive potential of MMP inhibitors for pre-malignant intestinal tumors. In contrast, forced TIMP-1 expression in transgenic mice had no effect or, in one line, unexpectedly augmented Min tumor multiplicity by 32%. Th

Who reads Differing Effects of Endogenous and Synthetic Inhibitors of Metalloproteinases on Intestinal Tumorigenesis?

Author

Kathleen J. Heppner Goss; Peter D. Brown; Lynn M. Matrisian

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

1998

Language

EN

Field

Medicine (Health Sciences)