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Dinucleotide polymorphism of p73 gene is associated with a reduced risk of lung cancer in a Chinese population by Zhibin Hu; Xiaoping Miao; Hongxia Ma; Wen Tan; Xinru Wang; Daru Lu; Qingyi Wei; Dongxin Lin; Hongbing Shen is a Medicine article available to read on EtoBox.

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## Abstract __p73__, a structural and functional homologue of __p53__, shares some p53‐like tumor suppressor activity but also possesses oncogenic activity. Therefore, __p73__ plays an important role in modulating cell‐cycle control and apoptosis. A potentially functional dinucleotide polymorphism, G4C14‐to‐A4T14, has been identified in the 5′ untranslated region (UTR) of exon 2 of the __p73__ gene, which may theoretically form a stem‐loop structure and affect gene expression. To test the hypothesis that these 2 common variants play a role in lung cancer susceptibility, we conducted a case‐control study of 425 lung cancer patients and 588 cancer‐free controls frequency‐matched to the cases on age and sex in a Chinese population. The results showed that these 2 polymorphisms were in complete linkage disequilibrium and the frequencies of variant __p73__ AT haplotype (A4T14) were less common in the cases (0.225) than in the controls (0.287) (__p__ = 0.0018), suggesting that this AT haplotype was protective against lung cancer. Compared to the __p73__ GC/GC homozygotes, both the AT/AT variant homozygotes and GC/AT heterozygotes were associated with a significantly decreased risk (adjus

Who reads Dinucleotide polymorphism of p73 gene is associated with a reduced risk of lung cancer in a Chinese population?

Author

Zhibin Hu; Xiaoping Miao; Hongxia Ma; Wen Tan; Xinru Wang; Daru Lu; Qingyi Wei; Dongxin Lin; Hongbing Shen

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2004

Language

EN

Field

Medicine (Health Sciences)