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The document discusses the implications of nonadherence in randomized clinical trials (RCTs), particularly focusing on the CABANA trial which examined the effects of catheter ablation versus drug therapy for atrial fibrillation. It explains the differences between intention-to-treat (ITT), per-protocol (PP), and as-treated (AT) analyses, highlighting how these approaches can lead to varying interpretations of treatment effects. The authors emphasize the importance of understanding these methodologies to acc

Author

Thắng Lữ

Language

EN