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Temporal Variation of C-fos Proto-oncogene Expression During Osteoblast Differentiation and Osteogenesis in Developing Rat Bone by M. Machwate; A. Jullienne; M. Moukhtar; Dr. P. J. Marie is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Temporal Variation of C-fos Proto-oncogene Expression During Osteoblast Differentiation and Osteogenesis in Developing Rat Bone about?

## Abstract To delineate the implication of c‐fos protooncogenic in the osteogenie process, we have investigated the temporal pattern of c‐fos mRNA expression in fetal and neonatal rat bone during intramembranous and endochondral bone formation. Northern blot analysis of mRNA extracted from calvaria and femur showed that expression of c‐fos, Histone H4, and osteocalcin mRNAs followed a temporal sequence during bone development. The levels of histone H4 mRNA, a marker of cell proliferation, were high at early stages of fetal development of calvaria and femur, and decreased until birth. In both the postnatal calvaria and femur, c‐fos mRNA levels increased transiently at birth and preceded a rise in osteocalcin transcripts, a marker of the mature osteoblast phenotype. The immunohistochemical analysis showed that c‐fos protein was expressed in osteoprogenitor cells in the perichondrium and periosteum, and not in mature osteoblasts which expressed markers of differentiated osteoblasts such as type‐I collagen, bone sialoprotein, and osteocalcin. Thus, the transient c‐fos proto‐oncogene expression during the postnatal life that precedes the osteocalcin expression may be involved in the tr

Who reads Temporal Variation of C-fos Proto-oncogene Expression During Osteoblast Differentiation and Osteogenesis in Developing Rat Bone?

Author

M. Machwate; A. Jullienne; M. Moukhtar; Dr. P. J. Marie

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0730-2312)

Published

1995

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)