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Altered Activation/detoxication Enzymology Following Neonatal Diethylstilbestrol Treatment by Coral A. Lamartiniere; Guillermo A. Pardo is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Altered Activation/detoxication Enzymology Following Neonatal Diethylstilbestrol Treatment about?

The effects of neonatal exposure to diethylstilbestrol (DES) on hepatic activation/detoxication enzyme levels in the adult rat were investigated. Neonatal exposure of male rats to DES (DES males) decreased the endogenous levels of UDP-glucuronyltransferase as compared to control males. Female rats exposed neonatally to DES (DES females) had higher endogenous epoxide hydrolase and glutathione transferase activity levels than control females. Adult animals treated neonatally with DES also had altered metabolic potential following exposure to 3-methylcholanthrene and phenobarbital. The DES males treated in adulthood with 3-methylcholanthrene had higher benzo(a)pyrene hydroxylase activities and lower UDP-glucuronyl-transferase activity levels than did control males treated in adulthood with 3-methylcholanthrene. The DES males exposed in adulthood to phenobarbital had reduced cytochrome P-450 and glutathione transferase activity levels as compared with respective controls. The DES females treated in adulthood with 3-methylcholanthrene had lower benzo(a)pyrene hydroxylase and epoxide hydrolase activity levels than control females receiving 3-methylcholanthrene. The DES females challenged

Who reads Altered Activation/detoxication Enzymology Following Neonatal Diethylstilbestrol Treatment?

Author

Coral A. Lamartiniere; Guillermo A. Pardo

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); VCH Publishers; Wiley (ISSN 0887-2082)

Published

1987

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)