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Evaluation of expression and function of the H+/myo-inositol transporter HMIT by Elena Di Daniel; Man HS Mok; Emma Mead; Chiara Mutinelli; Erika Zambello; Laura L Caberlotto; Theresa J Pell; Christopher J Langmead; Ajit J Shah; Graham Duddy; James NC Kew; Peter R Maycox is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Evaluation of expression and function of the H+/myo-inositol transporter HMIT about?
## Background: The phosphoinositide (pins) signalling pathway regulates a series of neuronal processes, such as neurotransmitter release, that are thought to be altered in mood disorders. furthermore, mood-stabilising drugs have been shown to inhibit key enzymes that regulate pins production and alter neuronal growth cone morphology in an inositol-reversible manner. here, we describe analyses of expression and function of the recently identified h+/myo-inositol transporter (hmit) investigated as a potential regulator of pins signalling. ## Results: We show that hmit is primarily a neuronal transporter widely expressed in the rat and human brain, with particularly high levels in the hippocampus and cortex, as shown by immunohistochemistry. the transporter is localised at the golgi apparatus in primary cultured neurones. no hmit-mediated electrophysiological responses were detected in rat brain neurones or slices; in addition, inositol transport and homeostasis were unaffected in hmit targeted null-mutant mice. ## Conclusion: Together, these data do not support a role for hmit as a neuronal plasma membrane inositol transporter, as previously proposed. however, we observed that hmit c
Who reads Evaluation of expression and function of the H+/myo-inositol transporter HMIT?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Elena Di Daniel; Man HS Mok; Emma Mead; Chiara Mutinelli; Erika Zambello; Laura L Caberlotto; Theresa J Pell; Christopher J Langmead; Ajit J Shah; Graham Duddy; James NC Kew; Peter R Maycox
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, [2000]-2018.; Springer Science and Business Media LLC (ISSN 1471-2121)
- Published
- 2009
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)