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Adsorption of human insulin and AspB28 insulin on a PTFE-like surface by S.H. Mollmann; J.T. Bukrinsky; S. Frokjaer; U. Elofsson is a Chemistry article available to read on EtoBox.

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The interactions of human insulin, Zn-free human insulin, and AspB28 insulin with a hydrophobic surface were studied by ellipsometry. All three insulin types investigated adsorbed with high affinity onto the hydrophobic surface, as the plateau of the adsorption isotherm, represented by the irreversible bound fraction, was reached at concentrations >10(-3) mg/ml. The plateau values for human insulin and Zn-free human insulin could not be distinguished with statistical significance, whereas the plateau value for AspB28 insulin was lower than those for the two others, with an adsorbed amount corresponding to a monolayer of insulin monomers. The results observed may be explained by differences in self-association patterns of the insulin types or by enhanced charge repulsion between the AspB28 analog and the negatively charged surface.

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Author

S.H. Mollmann; J.T. Bukrinsky; S. Frokjaer; U. Elofsson

Publisher

Elsevier Science; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0021-9797)

Published

2005

Language

EN

Field

Chemistry (Physical Sciences)