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Novel approaches in polyepitope T-cell vaccine development against HIV-1 by Larisa I Karpenko; Sergei I Bazhan; Denis V Antonets; Igor M Belyakov is a Medicine article available to read on EtoBox.

What is Novel approaches in polyepitope T-cell vaccine development against HIV-1 about?

RV144 clinical trial was modestly effective in preventing HIV infection. New alternative approaches are needed to design improved HIV-1 vaccines and their delivery strategies. One of these approaches is construction of synthetic polyepitope HIV-1 immunogen using protective T-and B-cell epitopes that can induce broadly neutralizing antibodies and responses of cytotoxic (CD8 + CTL) and helpers (CD4 + Th) T-lymphocytes. This approach seems to be promising for designing of new generation of vaccines against HIV-1, enables in theory to cope with HIV-1 antigenic variability, focuses immune responses on protective determinants and enables to exclude from the vaccine compound that can induce autoantibodies or antibodies enhancing HIV-1 infectivity. Herein, the authors will focus on construction and rational design of polyepitope T-cell HIV-1 immunogens and their delivery, including: advantages and disadvantages of existing T-cell epitope prediction methods; features of organization of polyepitope immunogens, which can generate high-level CD8 + and CD4 + T-lymphocyte responses; the strategies to optimize efficient processing, presentation and immunogenicity of polyepitope constructs; origin

Who reads Novel approaches in polyepitope T-cell vaccine development against HIV-1?

Author

Larisa I Karpenko; Sergei I Bazhan; Denis V Antonets; Igor M Belyakov

Publisher

Informa UK Limited

Published

2013

Language

EN

Field

Medicine (Health Sciences)