Can I read Disease-associated Patterns of Disomic Chromosomes in Hyperhaploid Neoplasms on EtoBox?

Disease-associated Patterns of Disomic Chromosomes in Hyperhaploid Neoplasms by Nils Mandahl; Bertil Johansson; Fredrik Mertens; Felix Mitelman is a Medicine article available to read on EtoBox.

What is Disease-associated Patterns of Disomic Chromosomes in Hyperhaploid Neoplasms about?

## Abstract The chromosome number of human tumors varies widely, from near‐haploidy to more than decaploidy. Overt hyperhaploid (24–34 chromosomes) tumors constitute a small minority (0.2–0.3% of cytogenetically investigated lesions), but occur in many different disease entities. In these karyotypes, most chromosomes are present in one copy; one or a few chromosomes are disomic. Published reports on 141 strictly hyperhaploid tumors, supplemented with nine previously unpublished cases, were used for evaluating the pattern of disomic chromosomes. Only one tumor type, acute lymphoblastic leukemia (ALL), was sufficiently common (__n__ = 75) to allow proper evaluation; other neoplasms were lumped together in as reasonably logical groups as possible, including 10 myeloid leukemias (ML), nine plasma cell neoplasms (PCN), 13 chondrosarcomas (CS), 11 soft tissue tumors (STT), nine adeno‐ or squamous cell carcinomas (ASC), and eight tumors of the nervous system (TNS); the remaining 15 tumors could not be grouped. It was evident that the pattern of disomies is nonrandom. Moreover, unique signatures for each tumor group were detected. Among ALL, most disomies were independent of age and gender

Who reads Disease-associated Patterns of Disomic Chromosomes in Hyperhaploid Neoplasms?

Author

Nils Mandahl; Bertil Johansson; Fredrik Mertens; Felix Mitelman

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 1045-2257)

Published

2012

Language

EN

Field

Medicine (Life Sciences)