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Effects of CYP1A2 and ADORA2A Genotypes on the Ergogenic Response to Caffeine in Professional Handball Players by Alejandro Muñoz; Álvaro López-Samanes; Millán Aguilar-Navarro; David Varillas-Delgado; Jesús Rivilla-García; Víctor Moreno-Pérez; Juan Del Coso is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Previous investigations have found that several genes may be associated with the interindividual variability to the ergogenic response to caffeine. The aim of this study is to analyze the influence of the genetic variations in CYP1A2 (−163C > A, rs762551; characterized such as “fast” (AA genotype) and “slow” caffeine metabolizers (C-carriers)) and ADORA2A (1976T > C; rs5751876; characterized by “high” (TT genotype) or “low” sensitivity to caffeine (C-carriers)) on the ergogenic response to acute caffeine intake in professional handball players. Thirty-one professional handball players (sixteen men and fifteen women; daily caffeine intake = 60 ± 25 mg·d−1) ingested 3 mg·kg−1·body mass (bm) of caffeine or placebo 60 min before undergoing a battery of performance tests consisting of a countermovement jump (CMJ), a sprint test, an agility test, an isometric handgrip test, and several ball throws. Afterwards, the handball players performed a simulated handball match (2 × 20 min) while movements were recorded using inertial units. Saliva samples were analyzed to determine the genotype of each player for the −163C > A polymorphism in the CYP1A2 gene (rs762551) and for the 1976T > C po

Who reads Effects of CYP1A2 and ADORA2A Genotypes on the Ergogenic Response to Caffeine in Professional Handball Players?

Author

Alejandro Muñoz; Álvaro López-Samanes; Millán Aguilar-Navarro; David Varillas-Delgado; Jesús Rivilla-García; Víctor Moreno-Pérez; Juan Del Coso

Publisher

MDPI AG

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)