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Can I read Macrophage- and Dendritic-Cell-Derived Interleukin-15 Receptor Alpha Supports Homeostasis of Distinct CD8+ T Cell Subsets on EtoBox?
Macrophage- and Dendritic-Cell-Derived Interleukin-15 Receptor Alpha Supports Homeostasis of Distinct CD8+ T Cell Subsets by Erwan Mortier; Rommel Advincula; Leesun Kim; Stephen Chmura; Julio Barrera; Boris Reizis; Barbara A. Malynn; Averil Ma is a Immunology and Microbiology article available to read on EtoBox.
What is Macrophage- and Dendritic-Cell-Derived Interleukin-15 Receptor Alpha Supports Homeostasis of Distinct CD8+ T Cell Subsets about?
Interleukin-15 receptor alpha (IL-15R alpha) is a pleiotropically expressed molecule that chaperones and trans-presents IL-15 to NK and T cells. To investigate whether IL-15R alpha presented by different cells perform distinct physiological functions, we have generated four lines of mice lacking IL-15R alpha in various cell types. We find that IL-15R alpha expression on macrophages but not dendritic cells (DCs) supports the early transition of antigen specific effector CD8(+) T cells to memory cells. After memory CD8(+) T cell differentiation, IL-15R alpha expression on DCs selectively supports central memory CD8(+) T cells, whereas IL-15R alpha expression on macrophages supports both central and effector memory CD8(+) T cells. By contrast, mice lacking IL-15R alpha on macrophages, DCs, or both, exhibit equivalent defects in NK cell homeostasis and activation. These studies define unique roles for macrophage expression of IL-15R alpha and show that NK cells rely upon distinct IL-15R alpha dependent IL-15 signals than memory CD8(+) T cells. Moreover, they demonstrate the diversity, specification, and geographic restriction of cytokine signals.
Who reads Macrophage- and Dendritic-Cell-Derived Interleukin-15 Receptor Alpha Supports Homeostasis of Distinct CD8+ T Cell Subsets?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Erwan Mortier; Rommel Advincula; Leesun Kim; Stephen Chmura; Julio Barrera; Boris Reizis; Barbara A. Malynn; Averil Ma
- Publisher
- Elsevier Science; Elsevier ; Cell Press; Elsevier BV (ISSN 1074-7613)
- Published
- 2009
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)